Biosensor Based on Fluorescent Spherical Resonator Using Polystyrene Microbead
نویسندگان
چکیده
This paper presents an on-chip biosensor using a polystyrene fluorescent microsphere as an optical resonator to enhance the fluorescence emission. The microsphere is attached on the wall of a microchannel in a polydimethylsiloxane (PDMS) optofluidic chip and excited by a focused laser beam using a confocal Raman microscope system. Based on the shift of Whispering Gallery modes (WGMs), this sensor has a resolution of 0.1% for protein concentration detection. Combined with the micro-opto-fluidic-system (MOFS), the biosensor has the advantage of tiny volume detection and high resolution, which shows promise in many applications such as real time biological analysis and environmental monitoring.
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